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| Name | Profession | Archetype | Connection | Special | Aspects | Faction |
|---|---|---|---|---|---|---|
| Saint Nick | "Santa Claus" | Gear | 2 | Blissfully Unaware KRIME Konnections Milk and Cookies Spirit of the Season We Got Guns | ||
| Sakata Amaterasu | Apprentice Weaponsmith | Custom(G,A,K,N) | 1 | Kobudō Supremacy Apprentice Weaponsmith | ||
| Sally Thin-Mints | Fence | Custom (G, K, N, A) | 1 | Consumer Grade Electronics | None | |
| Salvador "Sal" Ramone | Fixer | Networking | 5 | Hassle-Free Delivery It's the Music, Man! In the Mix Coming Soon! | ||
| Salvatore Marino | Finnigan Soldato | Custom(G,K,N,A) | 3 | Sex Sells Sometimes a Cigar is Just a Cigar Clothes Hound Black Market Enthusiast | Finnigan Family | |
| Sam Defabia-Kane | Owner: Seattle Staffing Solutions | Fixer | 3 | Streets of Downtown | ||
| Samantha (Sam) Forrester | Private Attorney | Legwork | 2 | Attorney Cutting a Deal Follow the Evidence | ||
| Sanev Beixidor | Talismonger | Custom (G,A,K,N) | 3 | Black Magician Enchanter Ritual Spellcaster Bought In Blue | ||
| Sanguine Lupe | Boss of the Direnetics | Custom(G,K,A,N) | 2 | Cybernetics Expert Bootleg Surgeon Seamless Integration | Direnetics Biker Gang | |
| Sanne "V10" Venneman | Mechanic | Service | 3 | Blissfully Unaware Motor Oil For Blood Let's Trick This Shit Out Safety First Ya Fucking Idiot Go-Gangers Again? One With The Machine | None | |
| Sapphi | Decker | Service | 3 | Motivated By Food Thrill Seeker Ready to Rumble Lady from Hades | Ladies from Hades | |
| Sarah Glenn | Stop Quick Owner | Custom(K,G,N,A) | 2 | Anti-Halloweener Drug Dealer Orkish Business Owner Heart of Gold | Anti-Halloweener | |
| Sarah Snow | Fundraiser and Housewife | Fixer | 3 | Novacoke? Novacoke! Dinner Parties of Metahumans Flawless Skin On Retainer Fundraiser | Team Alpha MERC | |
| Sarge | Arms Dealer | Gear | 5 | More Dakka Hidden Dakka Military Grade Black Market Connections Here comes the Boom Milsurp vehicles | Streets of Renton | |
| Saul Goodman | Baker | Custom(A,N,K,G) | 5 | Iron Chef Pastry Chef Bread Baker Artisanal Ingrediants World-Famous Baked Goods Improved Ability: Artisan (Baking) | ||
| Scrap | Fence | Gear | 2 | Electronics Black Market Connections Fence | ||
| Scraptrap | Junker Mechanic | Gear | 3 | Family Ties Fixer Upper I Know a Guy Hopping the Fence | ||
| Screamer | Shamanic Superheroine | Custom(N,A,G,K) | 2 | Aspected Shamanic Summoner Channeler Superhero | City Watch | |
| Sean Dempsey | Adjunct College Professor | Custom (K,N,A,G) | 2 | Rugby Hooligan Celtic Mythology Professor I Spend Most Of My Time At University | ||
| Sebastian “Perfect Fit” Schmidt | Horizon Studios Head of Wardrobe | Gear | 3 | Blissfully Unaware Overworked Pre-Production Blues Tailor Made Theatrical Flourish Apprenticed At Armani Simsense Procurement Stunt Design The Science of Dyeing Representation Matters | Horizon | |
| SegFault's Team | Shadowrunner Team | Service | 4 | Saeder-Krupp Fugitives Emerged Archery Black Mage Rigger Team Tactics Strong Morals | Unaffiliated | |
| Selena Hernandez | Vehicle Stock Manager. | Gear | 5 | Hot Wheels Like a Bird Not Afraid to get hands dirty. Come Into My shop Playing a Dangerous Game | Aztechnology | |
| Senator Alexander Hollaway | UCAS Senator | Networking | 8 | Example Negative Aspect Example Positive Aspect Warhawk | Archconservative Party | |
| Septu | Safehouse Master | Custom(N,K,A,G) | 5 | Safe as houses Out of the way squats With Extra Security on Top Retired Runner Seattle Native I Fought the Law | ShadowHaven | |
| Sergeant Dornan & Daughter | Retired Sergeant/Security Spider | Service | 3 | Broken Mind Sergeant Laser I WORKED FOR A LIVING YOU MO-RON ! Young Prodigy Insider Family Friends | ||
| Serpent | Talismonger | Gear | 5 | Spirits Aztechnology Talismonger Paracritter Spellcaster Aztec Religion | Streets of Redmond | |
| Severija | Night Club Hostess | Legwork | 1 | Arm's Length Mmm Hmm Mmm-Hmm | Matchstick's | |
| Sgt. Billy Butcher | Soldier | Gear | 2 | Unreliable UCAS military connections Restricted armor. Restricted weapons Weapons training | UCAS Rangers | |
| Shane Fisher | Fishmonger | Generalist | 3 | Fishmonger What? You've never been bowfishing? We're gonna need a bigger boat... Yeah, I got room. | The Grocers | |
| Sharog | Fixer | Fixer | 4 | First Impression Corporate Mom Middle-Class Friends Cruel To Traitors Politically Active | ||
| Sharp Fang | Pack Leader | Service | 1 | Pack Leader Unarmed Combatant | ||
| Shen Tzi | Triad Street Soldier | Legwork | 5 | Yellow Lotus Triad | ||
| Shen Yu | Octagon Red Pole | Fixer | 4 | The Octagon Triad | ||
| Sholeetsa Two Birds | NABS-SSC Reporter | Legwork | 4 | Ain't No News Like Local News I Never Reveal My Sources Dogged Investigator Politics - The mother's milk of journalism. Follow the Money | NABS-SSC | |
| Shroud | Ex-Aztech Spider | Fixer(N,K,A,G) | 4 | Fungus Among Us Shroom and Gloom Support Network Support Network II Death Cap Data Sporage Solutions Psilocybe Aztecorum Hydnellum Peckii Yourcelium is Mycelium | ||
| Sid | Mechanic | Fixer(N,A,G,K) | 3 | Ex-Runner Rigger Engineer On The Low | ||
| Sidewalk | Free Spirit | Custom(A,K,N,G) | 2 | Earth Spirits Breaks stuff Roads | ||
| Sigrun Thorsdottir | Blizzard | Service | 6 | Weather Control Blizzard Endowment I RIDE FORTH! The Water Has Ears Pretty! A GREAT SAGA | ||
| Silas Vespasiano | Black Lodge Fixer | Fixer | 5 | Black Magician High Society Socialite Made Man Politico Talismonger Theory Savant | Black Lodge | |
| Silas and Thekla Economakos | Gardening Center Couple | Networking | 3 | Blissfully Unaware Family Time Working Hours Demeter Days The Big Ten Neighborhood Networking Choose a Word and I'll Show You It Comes from Greek… Pointy-Eared and Tusked Like Likes Like Snohomish Shadows | ||
| Sinéad Brown | Corporate Manager | Fixer | 6 | Saeder-Krupp | ||
| Sir Boris Aldrich Karl Von Altdorf of the Order of the Silver Torch | Knight | Fixer(K,A,N,G) | 3 | Dragonslayer Warden Vampire Hunter Cult Expert | Order of the Silver Torch | |
| Sir Reginald Corgington | Loyal Philanthropist | Generalist | 7 | Back in My Day Worldwide History Something of a Scholar Big Game Hunter Checking the Vault The Vault of Mysteries and Oddities. I've Assembled a Team... Safe Travels A Better World The Bestest Boy Global Force | The Corgington Estate | |
| Sister Hana | Nun | Generalist | 3 | Spirit Talker Arms and Armor of the Lord BurnOut Christian Theurgy Former Shadowrunner Decker | ||
| Sister Mary Gunrunner | Fixer | Fixer(G,K,N,A) | 2 | Smoker Voice and Smoldering Temper Small Time Operation Ask and You Shall Receive Divine Intruments for Dirty, Rotten Scoundrels Not Quite Communion Wafers Holy Ground All Roads Lead to Rome | None | |
| Skinshedder | Free Sprite | Service | 4 | Sprite Fragile Skinshedder Matrix Denizen Favored Gremlin Loyal Friend Untiring | Farraday's Clinic | |
| Skitters | Halloweener Rager | Custom(K,A,N,G) | 3 | Halloweeners | ||
| Slava Nikerosa | Retired Military, Retired Runner, Business Owner | Fixer | 5 | Military Contacts Firearms Armor Augmentations Forged Sins Black Market Connections | Independant | |
| Slick Willy | Cheap Motel Owner | Gear | 1 | I know a guy I know a guy and a gal | Violi Mafia Family | |
| Slippery Sam | Carwash | Service | 3 | Streets of Auburn |